Lack of efficacy of levetiracetam and worsening of epileptic negative myoclonus

Abstract

Epileptic negative myoclonus (ENM) is an infrequent seizure type seen in association with a variety of epileptic syndromes. It has been reported to occur in benign focal epilepsies of childhood and can be worsened by a number of antiepileptic medications. Levetiracetam widely used to treat positive myoclonus in diverse clinical situations has also been reported as a therapeutic option. We report two children with partial epilepsy that demonstrated induction of ENM in one and worsening of ENM in the second patient on levetiracetam.

Keywords

Epileptic negative myoclonus - levetiracetam - child